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Better Sleep

Pain Relief

Decreased Stress

Improved Immunity

Learn more about our 4 Board-Certified MD founders

Learn how MDbio products restore your endocannabinoid balance and maximize health

MDsleep

The clinically-proven supplement to help you get a good night’s sleep.

Helps calm the central nervous system

Quiets the mind

Includes full spectrum hemp and GABA

15% off on all subscription orders

Reschedule, hold, or cancel at any time

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30-day money-back guarantee

Product Details

Ingredient List

How to Use

MDsleep

MDsleep
MDsleep
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MDsleep
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MDsleep
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Sleep soundly, sleep naturally

MDsleep +hemp is a melatonin-free, non-intoxicating, relaxing nighttime supplement, clinically proven to promote and prolong restful sleep by calming the mind and the body.

Why MDsleep?

  • Includes full spectrum hemp
  • Non-psychoactive
  • Clinically tested
  • Promotes relaxation
  • Helps calm the central nervous system
  • Activates the endocannabinoid system
  • Quiets the mind
  • Made with quality, time tested herbs and botanicals

Our Formulas

  • Made with quality, time tested herbs and botanicals
  • Doctor Formulated
  • Cruelty Free
  • Patient Tested
  • Safe alternative pharmaceuticals

Scientifically formulated
for better sleep

MDsleep +hemp supports different pathways to sleep by helping the body achieve homeostasis or total equilibrium.

Full Spectrum Hemp
a clinical, non-intoxicating dose (less than 0.3% THC) activates the endocannabinoid system that regulates physiological and cognitive processes including the sleep cycle, the circadian rhythm and responses to stress and mood.
GABA
an inhibitory neurotransmitter that calms the mind by supporting the body’s central nervous system. L-Theanine - helps the body’s natural production of serotonin that eases stress and anxiety. Hops - a time-tested herb that has a sedative effect on the central nervous system to promote relaxation.
Valerian Root
boosts GABA and serotonin levels, promoting mind relaxation.

Proven Results

The efficacy of MDsleep +hemp formula has been scientifically proven through observational studies and a double-blind placebo-controlled clinical trial.

We invested in the largest non-melatonin clinical trial in history with 620 participants

Our solutions work with

The endocannabinoid system.

Our solutions work with the endocannabinoid system. Discovered in the 1990’s, the Endocannabinoid System (ECS) is a sophisticated biological “control system”.
Is it a complex matrix of cell receptors, neurotransmitters and enzymes that all work together to maintain homeostasis.
The largest system of biochemical receptors in our body, ECS is make of 3 parts:

Endocannabinoids in our body interact with specific parts of our cells called endocannabinoid receptors. These receptors are found on different types of cells in our body and can cause different reactions when activated. Scientists have studied two of these receptors of importance for the effects of
endocannabinoids.

  • Cannabinoid 1 (CB1) Receptors: They are primarily found in the central
    nervous system, especially in neurons or nerve cells in the brain. THC and
    anandamide also bind with these receptors..
  • Cannabinoid 2 (CB2) Receptors: Found in the peripheral nervous system
    and immune cells. They are like tiny keyholes unlocked by molecules
    called 2-AG. The CB2 receptors can help reduce inflammation and other
    immune responses.

Endocannabinoids are natural chemicals our bodies make, similar to those found in cannabis plants. Our body produces endocannabinoids when
required rather than in advance. The nervous system uses these chemicals to communicate with different body parts.

Your body can produce these chemicals because they come from fats –
everyone has an active ECS system. Dr. Larian outlines the role of an
endocannabinoid in regulating nervous impulses: “When these nerves feel that
the previous nerve is firing too hard… the extra input sends an
endocannabinoid. This extra chemical… …goes backward and tells the nerve,
‘Calm down. You’re working too hard. Go back to your baseline and restart.’”
Scientists have extensively researched two significant types of
endocannabinoids: 

  • The messenger or "bliss" molecule: Arachidonoyl ethanolamide
    (anandamide or AEA)
  • 2-AG: 2-arachidonoyl glycerol enhances the function of CB1 receptors
    and is the primary natural molecule that can bind to CB2 receptors.

Enzymes are natural substances our bodies produce to create and break
down certain chemicals. For example, when a cell needs to send a message, endocannabinoids are made by breaking down fats with the help of enzymes.
After the endocannabinoids do their job, they are removed from the cells by a particular protein and broken down further by other enzymes. Regarding endocannabinoids, two types of enzymes help break them down so they don't stay in our body for too long:: 

  • Fatty acid amide hydrolase (FAAH): findings suggest that FAAH has a natural ability to break down anandamide and 2-AG.
  • Monoacylglycerol acid lipase (MAG-L): Once the 2-AG molecule has completed its function, it is taken back into the cells and broken down by an enzyme called MAGL. The body uses the broken-down product to produce other compounds.


Understanding how these enzymes work could help create new treatments for
diseases like addiction.

Learn more

Looking for our
botanical blend?

MDsleepTM Botanical

It combines a harmonizing blend of traditionally time-tested herbs with key amino acids to promote and prolong restful sleep.

Shop now

Still unsure about choosing
hemp or botanical?

306 Reviews
Real reviews by real people who take MDsleep

average rating 4.9 out of 5
Based on 306 reviews
  • 5 Stars
    273 Reviews
  • 4 Stars
    27 Reviews
  • 3 Stars
    6 Reviews
  • 2 Stars
    0 Reviews
  • 1 Star
    0 Reviews
98% of reviewers would recommend this product to a friend
306 Reviews
Reviewed by Nancy L.
Verified Buyer
MDsleep
Reviewing
MDsleep
I recommend this product
Age Range
65+
Symptoms
  • Sleeplessness
Product Qualities
  • Effective
Rated 5 out of 5
Review posted

MD sleep

it seems to be working and i am getting sleep

which is wonderful

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Reviewed by Michael J B.
Verified Buyer
MDsleep
Reviewing
MDsleep
I recommend this product
Age Range
65+
Symptoms
  • Anxiety
  • Sleeplessness
Product Qualities
  • Useful
Rated 4 out of 5
Review posted

Product is well formulated but after taking it before bedtime with water, I later woke up with a horrible taste in my mouth.

It really was not effective for me and gave me a bad taste in my mouth after the tablets dissolved. Maybe it was my reaction to the product. I know the product contains ingredients that should work for most people.

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Reviewed by Patricia M.
Verified Buyer
I recommend this product
Rated 5 out of 5
Review posted

Love it

Love the new packaging.

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Ask Us Anything.

We’re an Open Book.

We put a lot of thoughts into creating these optimal blends for top chronic conditions. Our team of doctors and experts are happy to answer your questions.

What is that taste and smell?

Each product has a distinctive taste and aroma. While we strive to minimize excess smell and flavor, it's challenging to completely mask the botanical elements packed into each softgel. Consider the taste and smell as indicators of the potent ingredients within. If your previous herbal supplement lacks these characteristics, it may contain undesirable fillers and additives. Our commitment is to keep our products clean and natural.

When should I take MDsleep?

Think of MDsleep as the first chapter of your bedtime story. Pop it in 30 - 60 minutes before you plan to hit the hay, right when you're starting your "get ready for dreamland" routine.

How much should I take?

Your body's like a custom-made suit—no one size fits all here. Start with 2 softgels for 3 days, and then adjust depending on how you have felt. If you need an extra softgel with each dose because two wasn’t doing the trick, take 3. If you have been experiencing mild side effects such as grogginess, decrease to 1 softgel per dose. The key to finding a therapeutic dose of MDbio products is through consistency.

Why did you add Full Spectrum Hemp to MDsleep and what does it do?

"Full Spectrum" is our way of saying we're embracing all the good stuff from the hemp plant (including trace amounts of THC). It’s like a team: everyone brings something unique to the table. And just like our bodies have evolved over ages with a built-in system (the “endocannabinoid” system) that touches everything we do, we believe that harnessing the full power of hemp makes the perfect tag team.

Why don’t I see terpenes listed in the ingredients?

Oh, those sneaky terpenes! They’re naturally wrapped up in the hemp plant, so when you see "full spectrum hemp" in our MDsleep, know there's a chorus of terpenes playing their part. But in our MDsleep Botanical Blend, we've added a special mix, our own Bio-Terpene Complex, to ensure you're not missing out on any of those harmonious notes.

I have trouble taking pills, what can I take with MDsleep +hemp to make the softgels more palatable?

Our product ingredients come from plants and may have earthy or grassy flavors due to minimal processing and fewer additives. If you find the taste unpleasant, try mixing it with yogurt, honey, juice, smoothies, or other beverages to minimize the flavor while still enjoying the potential health benefits.

If I am taking a pharmaceutical product for sleep, how do I transition to a plant alternative?

Your primary care physician can help you switch from pharmaceuticals to our plant medicine. We've found that slowly transitioning over time works best, depending on how severe your symptoms are.

What if I still had some sleeplessness on my first night?

Most users need three consecutive nights to start feeling the effects of MDsleep, but it's actively working in the meantime. The benefits unfold with consistent use, as MDsleep is crafted to align with your natural sleep patterns rather than providing an immediate "lights out" effect like pharmaceuticals

If I wake in the middle of the night, should I take another softgel?

If you feel the product isn't effectively targeting your symptoms, consider increasing the dosage to a maximum of 3 softgels per dose. Those with severe or frequent symptoms often find optimal therapeutic effects with this amount. Avoid taking MDbio products on an empty stomach; instead, consume them with a spoonful of yogurt, cracker, sandwich, etc.

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